白い歯は第一印象に影響大。
老け顔の原因は「歯」。

誰もが憧れる白い歯を、毎日の歯磨きでつくりたい！
そんな思いに応える、いま話題の新ホワイトニング成分「EXポリリン酸®」の効果と仕組みをご紹介します。

EXポリリン酸®は

  • 人体にもある
    天然成分
    で身体に優しい
  • 再生医療研究
    から生まれた高品質
    ホワイトニング成分
  1. トップページ
  2. 学術論文

学術論文EXポリリン酸®

  1. R. Gawri, R. Bielecki, EW Salter, A. Zelinka, T. Shiba, G. Collingridge, A. Nagy, RA Kandel. The anabolic effect of inorganic polyphosphate on chondrocytes is mediated by calcium signalling. J Orthop Res., 40, 310-322 (2022)
  2. Y. Yamazaki, M. Terashima-Hasegawa, A. Manabe, T. Shiba, Y. Kawazoe, T. Ashino, M. Hosonuma, S. Numazawa. Inorganic polyphosphate modulates leukocyte accumulation and vascular endothelial cell permeability and ameliorates cecal ligation and puncture-induced lethality. Fundam. Toxicol. Sci. 8, 89-96 (2021)
  3. T. Tanaka, M. Terashima, Y. Iketani, Y. Kawazoe, T. Shiba, A. Manabe. Suppression of Demineralization by Inorganic Polyphosphates with Optimum Chain Length for Stain Removal and Prevention of Stain Deposition. Jpn. J. Conserv. Dent. 64, 107-115 (2021)
  4. S. Hosoda, Y. Kawazoe, T. Shiba, S. Numazawa, A. Manabe. Anti-Obesity Effect of Ginkgo Vinegar, a Fermented Product of Ginkgo Seed Coat, in Mice Fed a High-Fat Diet and 3T3-L1 Preadipocyte Cells. Nutrients, 16, 230 (2020)
  5. LK Seidlmayer, MR Gomez-Garcia, T. Shiba, GA Porter Jr, EV Pavlov, DM Bers, EN Dedkova. Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation. Arch Biochem Biophys. 662, 177-189 (2019)
  6. M. Terashima-Hasegawa, T. Ashino, Y. Kawazoe, T. Shiba, A. Manabe, S. Numazawa. Inorganic polyphosphate protects against lipopolysaccharide-induced lethality and tissue injury through regulation of macrophage recruitment. Biochem Pharmacol. 159, 96-105 (2019)
  7. X. Xu, D. Zhang, S. Gao, T. Shiba, Q. Yuan, K. Cheng, H. Tan, J. Li. Multifunctional Biomaterial Coating Based on Bio-Inspired Polyphosphate and Lysozyme Supramolecular Nanofilm. Biomacromolecules. 19, 1979-1989 (2018)
  8. R. Gawri, T. Shiba, R. Pilliar, R. Kandel. Inorganic polyphosphates enhances nucleus pulposus tissue formation in vitro. J Orthop Res. 35, 41-50 (2017)
  9. WD. Lee, R. Gawri, T. Shiba, AR. Ji, WL. Stanford, RA. Kandel, Simple silica column-based method to quantify inorganic polyphosphates in cartilage and other tissues., Cartilage, Mar. 1 (2017).
  10. H. Ogawa, C. Kurokawa, M. Hoshino, K. Tamaoka, T. Toko, T. Shiba, A. Manabe, Bleaching agent containing polyphosphate –Influence on bleaching effect, accumulation of stain, and prevention of decalcification-., Jpn. J Conserv. Dent., 59, 197-205 (2016).
  11. T. Shiba, Inorganic polyphosphate and its chain length dependency in periodontal tissue regeneration including bone remodeling and teeth whitening., in Chapter 10 of Inorganic Polyphosphates in Eukaryotic Cells., T. Kulakovskaya, E. Pavlov, EN. Dedkova Eds. (2016).
  12. LC. Wijeyewickrema, E. Lameignere, RC. Duncan, T. Shiba, RJ. Travers, PR. Kapopara, VL. Stephanie, H. Kim, JH. Morrissey, RN. Pike, EM. Conway, Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor., Blood, 128, 1766-1776 (2016).
  13. PR. Angelova, BK. Agrawalla, PA. Elustondo, J. Gordon, T. Shiba, AY. Abramov, YT. Chang, EV. Pavlov, In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8., ACS Chem. Biol., 9, 2101-2110 (2014).
  14. K. Doi, T. Kubo, R. Takeshita, S. Kajihara, S. Kato, Y. Kawazoe, T. Shiba, Y. Akagawa, Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study., Dent. Mater. J., 33, 179-186 (2014).
  15. M. Koyasu, T. Shiba, Y. Kawazoe, A, Manabe, T. Miyazaki, Ultraphosphate, a potent stain control agent that is effective for both stain removal and prevention of stain deposition., Dent. Mater. J., 33, 1-9 (2014).
  16. K. Tsutsumi, N. Saito, Y. Kawazoe, H-K. Ooi, T. Shiba, Morphogenetic study on the maturation of osteoblastic cell as induced by inorganic polyphosphate., PLOS ONE, 9, issue 2, e86834 (2014).
  17. K. Harada, H. Itoh, Y. Kawazoe, S. Miyazaki, K. Doi, T. Kubo, Y. Akagawa, T. Shiba, Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts., PLOS ONE, 8, issue 11, e78612 (2013).
  18. K. Harada, T. Shiba, K. Doi, K. Morita, T. Kubo, Y. Makihara, A. Piattelli, Y. Akagawa, Inorganic polyphosphate suppreses lipopolysaccharide-induced inducible nitric oxide synthase (iNOS) expression in macrophages., PLOS ONE, 8, issue 9, e74650 (2013).
  19. N. Sun, H. Zou, L. Yang, K. Morita, P. Gong, T. Shiba, Y. Akagawa, Q. Yuan, Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway., Biochem. Biophys. Res. Com., 428, 298-302 (2012).
  20. D. Morimoto, T. Tomita, S. Kuroda, C. Higuchi, S. Kato, T. Shiba, H. Nakagami, R. Morishita, H. Yoshikawa, Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells., J. Bone Miner. Metab., 28, 418-423 (2010).
  21. M. Yamaoka, M. Ishizuka, K. Ishihama, M. Takahashi, M. Takahashi, H. Yamada, Y. Teramoto, K. Yasuda, T. Shiba, T. Uematsu, K. Furusawa, Bone formation without lamina dura in the middle-aged and elderly: possible dependence on enamel., Clinical Interventions in Aging, 5, 37-43 (2010).
  22. K. Morita, K. Doi, T. Kubo, R. Takeshita, S. Kato, T. Shiba, Y. Akgagawa, Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite., Acta Biomaterialia, 6, 2808-2815 (2010).
  23. Q. Yuan, T. Kubo, K. Doi, K. Morita, R. Takeshita, S. Katoh, T. Shiba, P. Gong, Y. Akagawa, Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration., Acta Biomaterialia, 5, 1716-1724 (2009).
  24. Y. Kawazoe, S. Katoh, Y. Onodera, T. Kohgo, M. Shindoh, T. Shiba, Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate., Int. J. Biol. Sci., 4, 37-47 (2008).
  25. M. Yamaoka, T. Uematsu, T. Shiba, T. Matsuura, Y. Ono, M. Ishizuka, H. Naramoto, M. Takahashi, M. Sugiura-Tomita, K. Iguchi, S. Yamashita, K. Furusawa, Effect of inorganic polyphosphate in periodontitis in the elderly., Gerodontology., 25, 10-17 (2008).
  26. Y. Hacchou, T. Uematsu, O. Ueda, Y. Usui, S. Uematsu, M. Takahashi, T. Uchihashi, Y. Kawazoe, T. Shiba, S. Kurihara, M. Yamaoka, K. Furusawa., Inorganic polyphosphate: a possible stimulant of bone formation., J. Dent. Res., 86, 893-897 (2007).
  27. P. McInerney, T. Mizutani, T. Shiba, Inorganic polyphosphate interacts with ribosomes and promotes translation fidelity in vitro and in vivo. Mol. Microbiol. 60, 438-447 (2006).
  28. H. Itoh, Y. Kawazoe, T. Shiba, Enhancement of protein synthesis by an inorganic polyphosphate in an E. coli cell-free system., J. Microbiol. Methods. 64, 241-249 (2006).
  29. H. Zhang, N. N. Rao., T. Shiba, A. Kornberg, Inorganic polyphosphate in the social life of Myxococcus xanthus: Motility, development, and predation., Proc. Natl. Acad. Sci. USA 102, 13416-13420 (2005).
  30. T. Shiba, H. Itoh, A. Kameda, Y. Kawazoe, K. Kobayashi, T. Noguchi, Polyphosphate:AMP phosphotransferase as a polyphosphate dependent nucleoside monophosphate kinase in Acinetobacter johnsonii 210A., J. Bacteriol., 187, 1859-1865 (2005).
  31. H. Itoh and T. Shiba, Polyphosphate synthetic activity of polyphosphate:AMP phosphotransferase in Acinetobacter johnsonii 210A., J. Bacteriol. 186, 5178-5181 (2004).
  32. Y. Kawazoe, T. Shiba, R. Nakamura, A. Mizuno, K. Tsutsumi, T. Uematsu, M. Yamaoka, M. Shindoh, T. Kohgo, Induction of calcification in MC3T3-E1 cells by inorganic polyphosphate., J. Dent. Res. 83, 613-618 (2004).
  33. T. Shiba, Y. Takahashi, T. Uematsu, Y. Kawazoe, K. Ooi, K. Nasu, H. Itoh, H. Tanaka, M. Yamaoka, M. Shindoh, T. Kohgo, Effect of Inorganic Polyphosphate on Periodontal Regeneration., Key Engineering Materials, 254-256, 1119-1122 (2004).
  34. T. Shiba, D. Nishimura, Y. Kawazoe, Y. Onodera, K. Tsutsumi, R. Nakamura, M. Ohshiro, Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate., J. Biol. Chem. 278, 26788-26792 (2003).
  35. K. Ishige, T. Hashimoto, T. Shiba, T. Noguchi, Novel method for enzymatic synthesis of CMP-NeuAc., Biosci. Biotechnol. Biochem., 65, 1736-1740 (2001).
  36. A. Kameda, T. Shiba, Y. Kawazoe, Y. Satoh, Y. Ihara, K. Ishige, T. Noguchi, A novel regeneration system using polyphsophate-AMP phosphotransferase and polyphosphate kinase., J. Biosci. Biotechnol. 9, 557-563 (2001).
  37. K, Tsutsumi, M. Munekata, T. Shiba, Involvement of inorganic polyphosphate in expression of SOS genes., Biochim. Biophys. Acta., 1493, 73-81 (2000).
  38. T. Miyake, T. Shiba, A. Kameda, Y. Ihara, M. Munekata, K. Ishige, T. Noguchi, The gene for exopolyphosphatase of Pseudomonas aeruginosa. DNA Research, 6, 103-108 (1999).
  39. T. Noguchi, T. Shiba, Use of Escherichia coli polyphosphate kinase for oligosaccharide synthesis., Biosci. Biotechnol. Biochem., 62, 1594-1596 (1998).
  40. K. Ishige, T. Shiba, T. Noguchi, The polyphosphate kinase gene of Pseudomonas aeruginosa. DNA research, 5, 157-162 (1998).
  41. T. Shiba, K. Tsutsumi, H. Yano, Y. Ihara, A. Kameda, T. Kan, H, Takahashi, M. Munekata, N. N. Rao, A. Kornberg, Inorganic polyphosphate and the induction of rpoS expression., Proc. Natl. Acad. Sci. USA 94, 15146-15152 (1997).
  42. H. Wurst, T. Shiba, A. Kornberg, The gene for a major exopolyphosphatase of Saccharomyces cerevisiae., J. Bacteriol. 177,898-906 (1995).